FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program
Abstract
Follicular regulatory T (Tfr) cells are a regulatory T cell subset that controls antibody production by inhibiting T follicular helper (Tfh)-mediated help to B cells. Tfh and Tfr cells possess opposing functions suggesting unique programming. Here we elucidated the transcriptional program controlling Tfr suppressive function. We found that Tfr cells have a program for suppressive function fine-tuned by tissue microenvironment. The transcription...
Paper Details
Title
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program
Published Date
Jan 31, 2019
Volume
216
Issue
3
Pages
605 - 620
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