Probing the Inhibition of Microtubule Affinity Regulating Kinase 4 by N-Substituted Acridones
Abstract
Microtubule affinity regulating kinase 4 (MARK4) becomes a unique anti-cancer drug target as its overexpression is responsible for different types of cancers. In quest of novel, effective MARK4 inhibitors, some acridone derivatives were synthesized, characterized and evaluated for inhibitory activity against human MARK4. Among all the synthesized compounds, three (7b, 7d and 7f) were found to have better binding affinity and enzyme inhibition...
Paper Details
Title
Probing the Inhibition of Microtubule Affinity Regulating Kinase 4 by N-Substituted Acridones
Published Date
Feb 8, 2019
Journal
Volume
9
Issue
1
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