Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts.
Abstract
Lipid droplets (LDs) are nutrient reservoirs used by cells to maintain homeostasis. Nascent droplets form on the endoplasmic reticulum (ER) and grow following an influx of exogenous fatty acids (FAs). The budding of LDs requires extensive ER-LD crosstalk, but how this is regulated remains poorly understood. Here, we show that sorting nexin protein Snx14, an ER-resident protein associated with the cerebellar ataxia SCAR20, localizes to ER-LD...
Paper Details
Title
Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts.
Published Date
Apr 1, 2019
Journal
Volume
218
Issue
4
Pages
1335 - 1351
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Notes
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