Original paper

Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy

Volume: 124, Issue: 8, Pages: 1198 - 1213
Published: Apr 12, 2019
Abstract
Rationale: LMNA (Lamin A/C), a nuclear membrane protein, interacts with genome through lamin-associated domains (LADs) and regulates gene expression. Mutations in the LMNA gene cause a diverse array of diseases, including dilated cardiomyopathy (DCM). DCM is the leading cause of death in laminopathies. Objective: To identify LADs and characterize their associations with CpG methylation and gene expression in human cardiac myocytes in DCM....
Paper Details
Title
Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy
Published Date
Apr 12, 2019
Volume
124
Issue
8
Pages
1198 - 1213
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