Anabolic signaling and response in sarcopenia as a model for microgravity induced muscle deconditioning: A systematic review

Muscle mass, sustained through buildup exceeding constant parallel breakdown, is mainly regulated through amino acid availability and mechanic stimulation and conveyed through the key mediator mTORC1. Sarcopenia, as age- and immobilization related loss of muscle mass, strength and function, may serve as an analog to muscle deconditioning in space travel. Optimal countermeasures to muscle deconditioning syndromes may be impacted by impaired...