Innate immune system

Lipid A

Enzyme

Immunology

Lipopolysaccharide

Staphylococcus aureus

Lipase

Bacteria

Genetics

Biochemistry

Biology

Immune system

Microbiology

Proceedings of the National Academy of Sciences

Commensal and pathogenic bacteria hydrolyze host lipid substrates with secreted lipases and phospholipases for nutrient acquisition, colonization, and infection. Bacterial lipase activity on mammalian lipids and phospholipids can promote release of free fatty acids from lipid stores, detoxify antimicrobial lipids, and facilitate membrane dissolution. The gram-positive bacterium

Bacterial lipolysis of immune-activating ligands promotes evasion of innate defenses