Cystic pancreatic neuroendocrine tumors: A more favorable lesion?

Published on Jan 22, 2019in Pancreatology3.629
· DOI :10.1016/J.PAN.2019.01.017
Rosalie A. Carr5
Estimated H-index: 5
(IU: Indiana University),
Panagiotis Bletsis1
Estimated H-index: 1
(IU: Indiana University)
+ 5 AuthorsEugene P. Ceppa23
Estimated H-index: 23
(IU: Indiana University)
Abstract Background Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs. Methods Patients with PNETs undergoing pancreatectomy between 1988 and 2016 at a high-volume center were reviewed retrospectively. Demographic, clinical, and histopathologic data were collected and analyzed. Results 347 patients with PNETs were identified; 27% (n = 91) were cystic. Patients with cystic PNETs were generally older (59 vs. 55 years, p = 0.05). Cystic PNETs were more commonly non-functional (95% vs. 82%, p = 0.004), asymptomatic (44% vs. 28%, p = 0.009), and located in the pancreatic body/tail (81% vs. 60%, p  Conclusion In addition to reporting a higher than previously published incidence of cystic PNET (27%), this study found significant differences in multiple clinicopathologic variables between cystic and solid PNETs. Cystic PNET may be a distinct and possibly less aggressive subtype of PNET yet have similar pathologic stage, recurrence, and survival to solid PNETs. Cystic PNETs require further attention to better understand the true natural history.
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