The senescence-associated secretory phenotype and its regulation
Abstract
The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context. The SASP reinforces the senescent cell cycle arrest, stimulates the immune-mediated clearance of potentially tumorigenic cells, limits fibrosis and promotes wound...
Paper Details
Title
The senescence-associated secretory phenotype and its regulation
Published Date
May 1, 2019
Journal
Volume
117
Pages
15 - 22
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Notes
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