The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer

Volume: 38, Issue: 21, Pages: 4015 - 4027
Published: Jan 28, 2019
Abstract
Aside from its well-known nuclear routes of signaling, estrogen also mediates its effects through cytoplasmic signaling. Estrogen signaling involves numerous posttranslational modifications of its receptor ERα, the best known being phosphorylation. Our research group previously showed that upon estrogen stimulation, ERα is methylated on residue R260 and forms the mERα/Src/PI3K complex, central to the rapid transduction of nongenomic estrogen...
Paper Details
Title
The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer
Published Date
Jan 28, 2019
Journal
Volume
38
Issue
21
Pages
4015 - 4027
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