Systematic literature review on the economic, humanistic, and societal burden of heart failure in children and adolescents.

Published on Mar 5, 2019in Expert Review of Pharmacoeconomics & Outcomes Research2.217
· DOI :10.1080/14737167.2019.1579645
Joseph W. Rossano44
Estimated H-index: 44
(Children's Hospital of Philadelphia)
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Abstract
ABSTRACTIntroduction: Unlike the adult heart failure (HF) patient population, there is scarce information on the overall burden of HF in the pediatric population across geographies and within diffe...
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References38
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#9Joseph W. Rossano (Children's Hospital of Philadelphia)H-Index: 44
While the epidemiology of adult heart failure has been extensively researched, this systematic review addresses the less well characterized incidence and prevalence of pediatric HF. The search strategy used Cochrane methodology and identified 83 unique studies for inclusion. Studies were categorized according to whether the HF diagnosis was reported as primary (n = 10); associated with other cardiovascular diseases (CVDs) (n = 49); or associated with non-CVDs (n = 24). A narrative synthesis of t...
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#1Robert E. Shaddy (Children's Hospital Los Angeles)H-Index: 53
#2Charles E. Canter (WashU: Washington University in St. Louis)H-Index: 66
Last. Fabian Chen (Novartis)H-Index: 2
view all 11 authors...
Background Sacubitril/valsartan (LCZ696) is an angiotensin receptor neprilysin inhibitor approved for the treatment of adult heart failure (HF); however, the benefit of sacubitril/valsartan in pediatric HF patients is unknown. Study design This global multi-center study will use an adaptive, seamless two-part design. Part 1 will assess the pharmacokinetics/pharmacodynamics of single ascending doses of sacubitril/valsartan in pediatric (1 month to Conclusion The PANORAMA-HF study, which will be t...
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#1Clyde W. YancyH-Index: 124
#2Mariell JessupH-Index: 79
Last. Cheryl WestlakeH-Index: 10
view all 17 authors...
Jonathan L. Halperin, MD, FACC, FAHA, Chair Glenn N. Levine, MD, FACC, FAHA, Chair-Elect Sana M. Al-Khatib, MD, MHS, FACC, FAHA Kim K. Birtcher, PharmD, MS, AACC Biykem Bozkurt, MD, PhD, FACC, FAHA Ralph G. Brindis, MD, MPH, MACC Joaquin E. Cigarroa, MD, FACC Lesley H. Curtis, PhD, FAHA
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Jonathan L. Halperin, MD, FACC, FAHA, Chair Glenn N. Levine, MD, FACC, FAHA, Chair-Elect Sana M. Al-Khatib, MD, MHS, FACC, FAHA Kim K. Birtcher, PharmD, MS, AACC Biykem Bozkurt, MD, PhD, FACC, FAHA Ralph G. Brindis, MD, MPH, MACC Joaquin E. Cigarroa, MD, FACC Lesley H. Curtis, PhD, FAHA
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ACC/AHA : American College of Cardiology/American Heart Association ACCF/AHA : American College of Cardiology Foundation/American Heart Association ACE : angiotensin-converting enzyme ACEI : angiotensin-converting enzyme inhibitor ACS : acute coronary syndrome AF : atrial fibrillation
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#2Kimberly Y. Lin (UPenn: University of Pennsylvania)H-Index: 14
Scarce data exist regarding costs of pediatric heart failure-related hospitalizations (HFRH) or how costs have changed over time. Pediatric HFRH costs, due to advances in management, will have increased significantly over time. A retrospective analysis of Healthcare Cost and Utilization Project Kids’ Inpatient Database was performed on all pediatric HFRH. Inflation-adjusted charges are used as a proxy for cost. There were a total of 33,189 HFRH captured from 2000 to 2009. Median charges per HFRH...
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OBJECTIVE: The use of ventricular assist devices has increased dramatically in adult heart failure patients. However, the overall use, outcome, comorbidities, and resource utilization of ventricular assist devices in pediatric patients have not been well described. We sought to demonstrate that the use of ventricular assist devices in pediatric patients has increased over time and that mortality has decreased. DESIGN: A retrospective study of the Pediatric Health Information System database was ...
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#1S. Law (Columbia University)H-Index: 8
#2Assaf P. Oron (Seattle Children's Research Institute)H-Index: 20
Last. Yuk M. Law (Seattle Children's)H-Index: 22
view all 7 authors...
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#2Kimberly Y. Lin (Children's Hospital of Philadelphia)H-Index: 14
#8Joseph W. Rossano (Children's Hospital of Philadelphia)H-Index: 44
Abstract Background Value-based health care is a proposed driver for reimbursement under the Affordable Care Act, with value broadly defined as outcomes divided by cost. Data on value-based health care in pediatric heart failure are scarce. Methods and Results A retrospective analysis of the Healthcare Cost and Utilization Project Kids' Inpatient Database and Nationwide Inpatient Sample was performed for pediatric and adult cardiomyopathy and heart failure–related hospitalizations. The study inc...
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Cited By1
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#1Raysa Morales-Demori (BCM: Baylor College of Medicine)H-Index: 2
#2Elena MontañesH-Index: 1
Last. Susan W. Denfield (BCM: Baylor College of Medicine)H-Index: 33
view all 6 authors...
The epidemiology of pediatric heart failure (HF) has been characterized for congenital heart disease (CHD) and cardiomyopathies (CM), but the impact of CM associated with CHD has not been studied. This study aims to describe the characteristics and outcomes of inpatient pediatric HF patients with CHD, CM, and CHD with CM (CHD + CM) across the USA. We included all HF patients with CM diagnoses with and without CHD using ICD 9/10 codes ≤ 19 years old from January 2004 to September 2019 using the P...
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