Probability of Opening during Recovery from Acetylcholine Receptor Desensitization
Abstract
Nicotinic acetylcholine receptors (AChRs) enter high-affinity, non-conducting, ‘desensitized’ (D) conformations upon sustained exposure to high concentrations of agonists. Desensitized conformations resemble functionally both resting (R; low-affinity, non-conducting) and active (R∗; high-affinity, ion-conducting) states. Previous experiments show that in the presence of agonists entry into D state(s) is mainly from R∗, but upon agonist washout...
Paper Details
Title
Probability of Opening during Recovery from Acetylcholine Receptor Desensitization
Published Date
Feb 1, 2019
Journal
Volume
116
Issue
3
Pages
394a - 394a
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