Multi-Scale Models of Deformation of Blood Clots

Thromboembolism, one of the leading causes of morbidity and mortality worldwide, is characterized by formation of obstructive intravascular clots (thrombi) and their mechanical breakage (embolization). A novel two-dimensional multi-phase computational model will be described that simulates active interactions between the main components of the clot, including platelets and fibrin. It can be used for studying the impact of various physiologically...