Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis
Abstract
Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcription factor Nrf2. Site-specific ROS release recruits Mst1/2 from the cytosol...
Paper Details
Title
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis
Published Date
Feb 14, 2019
Journal
Volume
10
Issue
1
Pages
755 - 755
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History