Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Volume: 10, Issue: 1, Pages: 755 - 755
Published: Feb 14, 2019
Abstract
Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcription factor Nrf2. Site-specific ROS release recruits Mst1/2 from the cytosol...
Paper Details
Title
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis
Published Date
Feb 14, 2019
Volume
10
Issue
1
Pages
755 - 755
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