Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets
Abstract
Our group previously demonstrated that overexpression of selenium-dependent glutathione peroxidase-1 (GPX1) in mice (OE) led to escalated glucose-stimulated insulin secretion and hyperinsulinemia. Because we found a strong correlation of this phenotype with a diminished expression of regenerating islet-derived protein 2 (REG2) in the OE pancreatic islets, the present study was to reveal underlying mechanisms for that down-regulation of REG2 by...
Paper Details
Title
Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets
Published Date
Apr 1, 2019
Volume
134
Pages
385 - 393
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