Targeting Pancreatic Stellate Cells in Cancer
Abstract
Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis with a 5-year survival rate of 8%. PSCs constitute more than 50% of the tumor stroma in PDAC, where they induce extensive desmoplasia by secreting abundant extracellular matrix (ECM) proteins. In addition, they establish dynamic crosstalk with cancer cells and other...
Paper Details
Title
Targeting Pancreatic Stellate Cells in Cancer
Published Date
Feb 1, 2019
Journal
Volume
5
Issue
2
Pages
128 - 142
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Notes
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