Bronchial Thermoplasty for Severe Asthma With Mucus Hypersecretion

Published on Jun 1, 2019in Internal Medicine1.005
· DOI :10.2169/INTERNALMEDICINE.1730-18
Naoko Nagano3
Estimated H-index: 3
,
Motoyasu Iikura21
Estimated H-index: 21
+ 3 AuthorsHaruhito Sugiyama19
Estimated H-index: 19
Sources
Abstract
: Bronchial thermoplasty (BT), which delivers thermal radiofrequency to the bronchial wall, is an effective therapy for patients with severe persistent uncontrolled asthma. We herein report the case of a 47-year-old man who underwent BT for uncontrolled severe asthma. After BT, his asthma control, asthma-related quality of life, and pulmonary function improved. Furthermore, a histologic examination of transbronchial biopsy specimens revealed a decrease in goblet cell hyperplasia and the smooth muscle mass as well as in the subepithelial basement membrane thickness. BT can be effective for patients with severe uncontrolled asthma and mucus hypersecretion.
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Rationale: Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle.Objectives: To evaluate the effectiveness and safety of BT versus a sham procedure in subjects with severe asthma who remain symptomatic despite treatment with high-dose inhaled corticosteroids and long-acting β2-agonists.Methods: A total of 288 adult subjects (Intent-to-Treat [ITT]) randomized to BT or sham control underwent three broncho...
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