Original paper
Loss of Endothelial Laminin α5 Exacerbates Hemorrhagic Brain Injury
Abstract
Endothelial cells make laminin-411 and laminin-511. Although laminin-411 is well studied, the role of laminin-511 remains largely unknown due to the embryonic lethality of lama5-/- mutants. In this study, we generated endothelium-specific lama5 conditional knockout (α5-TKO) mice and investigated the biological functions of endothelial lama5 in blood-brain barrier (BBB) maintenance under homeostatic conditions and the pathogenesis of...
Paper Details
Title
Loss of Endothelial Laminin α5 Exacerbates Hemorrhagic Brain Injury
Published Date
Jan 29, 2019
Volume
10
Issue
6
Pages
705 - 718
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Notes
History