Mitochondria-Targetable Ratiometric Time-Gated Luminescence Probe for Carbon Monoxide Based on Lanthanide Complexes

As a critical gasotransmitter, carbon monoxide (CO) has been demonstrated to be related with mitochondrial respiration, but the monitoring of CO in mitochondria remains a great challenge. In this work, a unique ratiometric time-gated luminescence (TGL) probe, Mito-NBTTA-Tb3+/Eu3+, that can specifically respond to mitochondrial CO has been developed. The probe was designed by incorporating a mitochondria-targeting moiety, triphenylphosphonium,...