Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
Abstract
Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents, and this is attributed to their ability to target MT dynamics and interfere with critical cellular functions, including, mitosis, cell signaling, intracellular trafficking, and angiogenesis. Because MT dynamics vary in the different stages of the cell cycle, these drugs tend to be the most effective against mitotic cells. While this class of drug has proven...
Paper Details
Title
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
Published Date
Feb 11, 2019
Journal
Volume
39
Issue
4
Pages
1398 - 1426
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