Ir-Catalyzed Intermolecular Branch-Selective Allylic C–H Amidation of Unactivated Terminal Olefins

An efficient method for intermolecular branch-selective allylic C–H amidation has been accomplished via Ir(III) catalysis. The reaction proceeds through initial allylic C–H activation, supported by the isolation and crystallographic characterization of an allyl-Ir(III) intermediate, followed by a subsequent oxidative amidation with readily available dioxazolones as nitrenoid precursors. A diverse range of amides are successfully installed at the...