ADIPOSE MESENCHYMAL STROMAL CELL CHARACTERISTICS ARE DIFFERENTLY MODULATED BY OSTEOARTHRITIC MILIEU

Mesenchymal stromal cells (MSCs) are promising candidate for cell therapy in osteoarthritis (OA) patients since that they exert anti-inflammatory, immunomodulatory, anti-fibrotic and anti-hypertrophic effects in the joint tissues. However, little is known about the OA milieu factors that could enhance the migration and tissue specific engraftment of exogenously injected MSC for successful regenerative cell therapy. GMP-clinical grade adipose...