Identification of forced degradation products of lacosamide by LC-QQLIT-MS and LC-IT/TOF-MS

Lacosamide, a new type of antiepileptic drug, was subjected to forced degradation under the conditions of hydrolysis (acidic and alkaline), oxidation, dry heat, and photolysis to characterize its possible degradation products. The drug showed significant degradation under acidic, alkaline and oxidative conditions. The degradation products were separated on an Agilent Zorbax SB-C 18 column with gradient elution using a mobile phase consisting of...