Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates
Abstract
Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial infections. Both theory and experiments have suggested that persisters facilitate genetic resistance by constituting an evolutionary reservoir of viable cells. Here, we provide evidence for a strong positive correlation between persistence and the likelihood to become genetically resistant in natural and lab strains of E. coli. This correlation can be...
Paper Details
Title
Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates
Published Date
Jan 15, 2019
Journal
Volume
13
Issue
5
Pages
1239 - 1251
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