Mechanisms of thrombocytopenia in platelet-type von Willebrand disease
Abstract
Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction. GPIbα and vWF play a role in megakaryocytopoiesis, thus we aimed to investigate megakaryocyte differentiation and proplatelet-formation in platelet-type von Willebrand disease using megakaryocytes from a patient...
Paper Details
Title
Mechanisms of thrombocytopenia in platelet-type von Willebrand disease
Published Date
Jan 17, 2019
Journal
Volume
104
Issue
7
Pages
1473 - 1481
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Notes
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