DMP1

Biochemistry

Bone resorption

Receptor

Semaphorin

Virus

Podocyte

Osteocyte

Viral matrix protein

Biology

Endocrinology

Bone remodeling

Estrogen

Osteoblast

Proteinuria

Kidney

Cell biology

VEGF receptors

SEMA3A

Neuropilin 1

Internal medicine

In vitro

Immunology

Osteoporosis

Vascular endothelial growth factor

Homeostasis

Medicine

Cell Metabolism

Menopause is associated with bone loss. Hayashi et al. show that estrogen induces expression of the osteoprotective protein semaphorin 3A (Sema3A), which acts on osteocytes to promote their survival and maintain bone homeostasis. An activator of soluble guanylate cyclase-cGMP signaling mimicked Sema3A action and ameliorated bone loss after ovariectomy.

Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging