BBS4 is required for IFT coordination and basal body number in mammalian olfactory cilia.

Bardet-Beidl Syndrome (BBS) manifests from genetic mutations encoding for one or more BBS proteins. BBS4 loss impacts olfactory ciliation and odor detection yet the cellular mechanisms remain unclear. Here, we report that Bbs4−/− mice exhibit shorter and fewer olfactory sensory neuron (OSN) cilia despite retaining odorant receptor localization. Within Bbs4−/− OSN cilia, we observed asynchronous rates of IFT-A/B particle movements indicating...