Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner

In the past few years, the endocannabinoid system has emerged as a pathophysiologically activated lipid signalling system in atherosclerosis and metabolic disorders.[1] Endocannabinoids are endogenous arachidonic acid-derived lipid mediators produced ‘on demand’ by the cleavage of membrane fatty acids, which bind to cannabinoid receptors CB1 and CB2. Clinical and experimental evidence based on pharmacological CB1 antagonism suggest a...