Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma.
Abstract
Recent studies have demonstrated recurrent activating mutations involving the classical MAPK and PI3K signaling pathways in a large proportion of histiocytic neoplasms, such as Langerhans cell histiocytosis. However, very little is known about the molecular genetics of histiocytic sarcoma, a rare aggressive malignant neoplasm that shows pathologic characteristics of mature macrophages. Here we report the genomic characteristics of a large cohort...
Paper Details
Title
Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma.
Published Date
Jan 9, 2019
Journal
Volume
32
Issue
6
Pages
830 - 843
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Notes
History