Distinct genome‐wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors

Background Aberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome‐wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs. Methods Thirty‐three tissue samples were analyzed: they included samples from sporadic (n = 9), von Hippel‐Lindau (VHL)‐related (n = 10), and multiple endocrine neoplasia type 1 (MEN1)–related...