Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex
Abstract
Glucocorticoids have various medical uses but are accompanied by side effects. The glucocorticoid receptor ( GR ) has been reported to regulate the clock genes, but the underlying mechanisms are incompletely understood. In this study, we focused on the suppressive effect of the GR on the expression of Rev‐erbα (Nr1d1), an important component of the clock regulatory circuits. Here we show that the GR suppresses Rev‐erbα expression via the...
Paper Details
Title
Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex
Published Date
Feb 1, 2019
Journal
Volume
593
Issue
4
Pages
423 - 432
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