Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Volume: 18, Issue: 2, Pages: 175 - 185
Published: Jan 14, 2019
Abstract
Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man–TLR7), which, when conjugated to antigens, elicits robust humoral and cellular immunity. p(Man–TLR7) is a random copolymer composed of monomers that either target dendritic cells (DCs) via mannose-binding receptors or activate DCs...
Paper Details
Title
Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity
Published Date
Jan 14, 2019
Volume
18
Issue
2
Pages
175 - 185
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