Total Synthesis and Anticancer Activity of (+)‐Hypercalin C and Congeners
Abstract
The hypercalins are dearomatized acylphloroglucinols with a pendant complex cyclopentane ring that exhibit activity against several cancer cell lines. We report the first total synthesis of (+)‐hypercalin C employing a convergent strategy that enabled the dissection of the essential structural features required for the observed anticancer activity. A strategic disconnection involving an unusual C –C Suzuki–Miyaura coupling with an α‐bromo...
Paper Details
Title
Total Synthesis and Anticancer Activity of (+)‐Hypercalin C and Congeners
Published Date
Feb 1, 2019
Journal
Volume
58
Issue
9
Pages
2734 - 2738
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