Original paper

Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection

Volume: 15, Issue: 1, Pages: e1007538 - e1007538
Published: Jan 4, 2019
Abstract
Staphylococcus aureus causes acute and chronic infections resulting in significant morbidity. Urease, an enzyme that generates NH3 and CO2 from urea, is key to pH homeostasis in bacterial pathogens under acidic stress and nitrogen limitation. However, the function of urease in S. aureus niche colonization and nitrogen metabolism has not been extensively studied. We discovered that urease is essential for pH homeostasis and viability in urea-rich...
Paper Details
Title
Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection
Published Date
Jan 4, 2019
Volume
15
Issue
1
Pages
e1007538 - e1007538
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