Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis

BackgroundRedox metabolism is often considered a potential target for cancer treatment, but a systematic examination of redox responses in hepatocellular carcinoma (HCC) is missing.MethodsHere, we employed systems biology and biological network analyses to reveal key roles of genes associated with redox metabolism in HCC by integrating multi-omics data.FindingsWe found that several redox genes, including 25 novel potential prognostic genes, are...