Safety of Biologic Therapy in Older Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis

Background & AimsManagement of immune-mediated inflammatory diseases often requires lifelong immunosuppression. Increasing numbers of older patients have inflammatory diseases and are particularly vulnerable to risks of immune suppressive therapies—particularly infections and malignancies.MethodsWe systematically searched PubMed/Medline and Embase to identify eligible studies that examined the safety of biologic therapies in older patients with...