DNA Topoisomerases in Unicellular Pathogens: Structure, Function, and Druggability

Topoisomerases from pathogenic members of a niche possess significant structural and functional differences from their nonpathogenic colleagues. Plasmodium and Toxoplasma, despite being apicomplexan parasites, differ from each other significantly in topoisomerase distribution, structure, and function. Few pathogens compensate the absence of a particular topoisomerase subtype by amplifying another topoisomerase variant. Kinetoplastid pathogens...