Tailored Ag–Cu–Mg multielemental nanoparticles for wide-spectrum antibacterial coating

Published on Jan 23, 2019in Nanoscale6.895
· DOI :10.1039/C8NR08375D
Giulio Benetti9
Estimated H-index: 9
(UCSC: Catholic University of the Sacred Heart),
Emanuele Cavaliere17
Estimated H-index: 17
(UCSC: Catholic University of the Sacred Heart)
+ 10 AuthorsLuca Gavioli22
Estimated H-index: 22
(UCSC: Catholic University of the Sacred Heart)
Bactericidal nanoparticle coatings are very promising for hindering the indirect transmission of pathogens through cross-contaminated surfaces. The challenge, limiting their employment in nosocomial environments, is the ability of tailoring the coating's physicochemical properties, namely, composition, cytotoxicity, bactericidal spectrum, adhesion to the substrate, and consequent nanoparticles release into the environment. We have engineered a new family of nanoparticle-based bactericidal coatings comprising Ag, Cu, and Mg and synthesized by a green gas-phase technique. These coatings present wide-spectrum bactericidal activity on both Gram-positive and Gram-negative reference strains and tunable physicochemical properties of relevance in view of their “on-field” deployment. The link between material and functional properties is rationalized based on a multidisciplinary and multitechnique approach. Our results pave the way for engineering biofunctional, fully tunable nanoparticle coatings, exploiting an arbitrarily wide number of elements in a straightforward, eco-friendly, high-throughput, one-step process.
📖 Papers frequently viewed together
25 Citations
31 Citations
11 Authors (Giulio Benetti, ..., Luca Gavioli)
16 Citations
#1Una Bogdanović (University of Belgrade)H-Index: 7
#2Suzana Dimitrijević (University of Belgrade)H-Index: 20
Last. Vesna Vodnik (University of Belgrade)H-Index: 18
view all 9 authors...
Abstract Copper nanoparticles (Cu NPs) have proven to own excellent antimicrobial efficacy, but the problems of easy oxidation and aggregation limit their practical application. Here, nanocomposite based on polyaniline (PANI) and Cu NPs solved this problem and brought additional physicochemical properties that are markedly advantageous for antimicrobial applications. Current work exploits this potential, to examine its time- and concentration-dependent antimicrobial activity, employing E. coli, ...
10 CitationsSource
Accessing fluid infiltration in nanogranular coatings is an outstanding challenge, of relevance for applications ranging from nanomedicine to catalysis. A sensing platform, allowing quantifying the amount of fluid infiltrated in a nanogranular ultrathin coating, with thickness in the 10–40 nm range, is here proposed and theoretically investigated by multiscale modeling. The scheme relies on impulsive photoacoustic excitation of hypersonic mechanical breathing modes in engineered gas-phase-synthe...
10 CitationsSource
#1Jaison Jeevanandam (Curtin University)H-Index: 13
#2Ahmed Barhoum (Vrije Universiteit Brussel)H-Index: 22
Last. Michael K. Danquah (Curtin University)H-Index: 43
view all 5 authors...
Nanomaterials (NMs) have gained prominence in technological advancements due to their tunable physical, chemical and biological properties with enhanced performance over their bulk counterparts. NMs are categorized depending on their size, composition, shape, and origin. The ability to predict the unique properties of NMs increases the value of each classification. Due to increased growth of production of NMs and their industrial applications, issues relating to toxicity are inevitable. The aim ...
792 CitationsSource
#1Mohammad Amin Jabbareh (HSU: Hakim Sabzevari University)H-Index: 3
#2Fatemeh Monji (HSU: Hakim Sabzevari University)H-Index: 2
Abstract Ag – Cu nanoparticles has been attracted a considerable attention due to their potential to use as catalysts, sensors and nano – solders. It is well known that the alloy nanoparticles have different phase stabilities than those observed in the bulk systems. Previous calculated results on phase stability of Ag – Cu nanoparticles showed relatively large differences with reported experimental data. Using recently modified CALPHAD type thermodynamic model, we reassess the phase diagram of A...
16 CitationsSource
#1Khwaja Salahuddin Siddiqi (AMU: Aligarh Muslim University)H-Index: 22
#2Azamal Husen (University of Gondar)H-Index: 25
Last. Rifaqat Ali Khan Rao (AMU: Aligarh Muslim University)H-Index: 22
view all 3 authors...
Use of silver and silver salts is as old as human civilization but the fabrication of silver nanoparticles (Ag NPs) has only recently been recognized. They have been specifically used in agriculture and medicine as antibacterial, antifungal and antioxidants. It has been demonstrated that Ag NPs arrest the growth and multiplication of many bacteria such as Bacillus cereus, Staphylococcus aureus, Citrobacter koseri, Salmonella typhii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia,...
338 CitationsSource
#1I. Wille (Innsbruck Medical University)H-Index: 1
#2A. Mayr (Innsbruck Medical University)H-Index: 16
Last. Cornelia Lass-Flörl (Innsbruck Medical University)H-Index: 52
view all 11 authors...
Summary Background In intensive care units (ICUs), inanimate surfaces and equipment may be contaminated by nosocomial pathogens, including multi-drug-resistant micro-organisms. Aims To assess the degree of environmental contamination close to and distant from patients, and contamination of healthcare workers' (HCWs) hands with nosocomial pathogens under real-life conditions and to investigate potential transmission events. Methods Over the course of three weeks, agar contact samples were taken c...
26 CitationsSource
#1Emanuele Cavaliere (UCSC: Catholic University of the Sacred Heart)H-Index: 17
#2Giulio Benetti (UCSC: Catholic University of the Sacred Heart)H-Index: 9
Last. Luca Gavioli (UCSC: Catholic University of the Sacred Heart)H-Index: 22
view all 6 authors...
: Nanocomposite systems and nanoparticle (NP) films are crucial for many applications and research fields. The structure-properties correlation raises complex questions due to the collective structure of these systems, often granular and porous, a crucial factor impacting their effectiveness and performance. In this framework, we investigate the optical and morphological properties of Ag nanoparticles (NPs) films and of Ag NPs/TiO₂ porous matrix films, one-step grown by supersonic cluster beam d...
11 CitationsSource
#1Ting Wei (Soochow University (Taiwan))H-Index: 15
#2Zengchao TangH-Index: 11
Last. Hong Chen (Soochow University (Taiwan))H-Index: 46
view all 4 authors...
The attachment and subsequent colonization of bacteria on the surfaces of synthetic materials and devices lead to serious problems in both human healthcare and industrial applications. Therefore, antibacterial surfaces that can prevent bacterial attachment and biofilm formation have been a long-standing focus of considerable interest and research efforts. Recently, a promising “kill–release” strategy has been proposed and applied to construct so-called smart antibacterial surfaces, which can kil...
145 CitationsSource
#1Evangelos I. Kritsotakis (University of Sheffield)H-Index: 15
#2Flora Kontopidou (CDC: Centers for Disease Control and Prevention)H-Index: 14
Last. Achilles GikasH-Index: 1
view all 6 authors...
Purpose: Assessing the overall burden of healthcare-associated infections (HAIs) is challenging, but imperative in evaluating the cost-effectiveness of infection control programs. This study aimed to estimate the point prevalence and annual incidence of HAIs in Greece and assess the excess length of stay (LOS) and mortality attributable to HAIs, overall and for main infection sites and tracer antimicrobial resistance (AMR) phenotypes and pathogens. Patients and methods: This prevalent cohort stu...
33 CitationsSource
#1Giulio BenettiH-Index: 9
#2Claudia CaddeoH-Index: 13
Last. Francesco BanfiH-Index: 20
view all 11 authors...
Ultrathin metal nanoparticles coatings, synthesized by gas-phase deposition, are emerging as go-to materials in a variety of fields ranging from pathogens control and sensing to energy storage. Predicting their morphology and mechanical properties beyond a trial-and-error approach is a crucial issue limiting their exploitation in real-life applications. The morphology and mechanical properties of Ag nanoparticle ultrathin films, synthesized by supersonic cluster beam deposition, are here assesse...
20 CitationsSource
Cited By27
3 CitationsSource
#1Yan Zhu (Kunming University of Science and Technology)H-Index: 88
#2Fang Zhou (Kunming University of Science and Technology)
Last. Edward Sacher (École Polytechnique de Montréal)H-Index: 54
view all 6 authors...
Abstract null null Colorless Ag-Cu nanoparticle (NP) dispersions have been prepared by heating polyvinyl pyrrolidone (PVP)- polyvinyl alcohol (PVA)-stabilized Ag NPs with Cu ions. They were characterized by TEM photomicrographs and UV-Visible spectroscopy. They showed high stability, and enhanced antibacterial effects against S. aureus, P. aeruginosa, E. coli and C. albicans. The antibacterial order decreased from Ag-Cu NPs to Ag NPs + Cu ions, to unheated Ag NPs, to heated Ag NPs.
#1Alessandro Di Cerbo (University of Camerino)H-Index: 16
#2Giuseppe Rosace (University of Bergamo)H-Index: 25
Last. Carla Sabia (University of Modena and Reggio Emilia)H-Index: 21
view all 10 authors...
One of the most-used food contact materials is stainless steel (AISI 304L or AISI 316L), owing to its high mechanical strength, cleanability, and corrosion resistance. However, due to the presence of minimal crevices, stainless-steel is subject to microbial contamination with consequent significant reverb on health and industry costs due to the lack of effective reliability of sanitizing agents and procedures. In this study, we evaluated the noncytotoxic effect of an amorphous SiOxCyHz coating d...
#1Gianluca RizziH-Index: 3
Last. Francesco BanfiH-Index: 20
view all 5 authors...
A 1D mechanical model for nanogranular films, based on a structural interface, is here presented. The analytical dispersion relation for the frequency and lifetimes of the acoustics breathing modes is obtained in terms of the interface layer thickness and porosity. The model is successfully benchmarked both against 3D Finite Element Method simulations and experimental photoacoustic data on a paradigmatic system available from the literature. A simpler 1D model, based on an homogenized interface,...
Structure, alloying and electronic properties of Mg-doped Cu$_nAg_{13-n} nano-clusters have been studied for all compositions, using first principles density functional theory. Similar to the undoped CuAg clusters, the Mg-doped clusters also retain core-shell structural pattern. Interestingly, the Mg-doping has increased the alloying property by inducing enhanced charge transfer among the constituting Cu as well as Ag atoms and thereby hybridization of their valence orbitals. Furthermore,...
1 CitationsSource
#1Theodore Manouras (FORTH: Foundation for Research & Technology – Hellas)H-Index: 6
#2Eleftherios Koufakis (FORTH: Foundation for Research & Technology – Hellas)H-Index: 3
Last. Maria Vamvakaki (FORTH: Foundation for Research & Technology – Hellas)H-Index: 49
view all 5 authors...
Hybrid, organic-inorganic, biocidal films exhibiting polishing properties were developed as effective long-lasting antimicrobial surface coatings. The films were prepared using cationically modified chitosan, synthesized by the reaction with 3-bromo-N,N,N-trimethylpropan-1-aminium bromide, to introduce permanent biocidal quaternary ammonium salt (QAS) groups along the polymer backbone and were cross-linked by a novel, pH-cleavable acetal cross-linker, which allowed polishing the hybrid coatings ...
3 CitationsSource
#1Carly Deusenbery (Brown University)
#2Yingying Wang (Brown University)H-Index: 6
Last. Anita Shukla (Brown University)H-Index: 16
view all 3 authors...
Bacterial infections are a major threat to human health, exacerbated by increasing antibiotic resistance. These infections can result in tremendous morbidity and mortality, emphasizing the need to identify and treat pathogenic bacteria quickly and effectively. Recent developments in detection methods have focused on electrochemical, optical, and mass-based biosensors. Advances in these systems include implementing multifunctional materials, microfluidic sampling, and portable data-processing to ...
2 CitationsSource
#1Federica Costantino (IIT: Istituto Italiano di Tecnologia)
Last. Despina FragouliH-Index: 25
view all 8 authors...
A photocatalytic system for the degradation of aqueous organic pollutants under visible light irradiation is obtained by an innovative approach based on ceria/platinum (Pt) hybrid nanoclusters on cellulose acetate fibrous membranes. The catalytic materials are fabricated by supersonic beam deposition of Pt nanoclusters directly on the surface of electrospun cellulose acetate fibrous mats, pre-loaded with a cerium salt precursor that is transformed into ceria nanoparticles directly in the solid m...
#1Juan Camilo Medina (UNAM: National Autonomous University of Mexico)H-Index: 10
#2Victor I García-Pérez (UNAM: National Autonomous University of Mexico)H-Index: 3
Last. Rodolfo Zanella (UNAM: National Autonomous University of Mexico)H-Index: 31
view all 3 authors...
Abstract Because the spread of antimicrobial resistance is impacting current health, environmental, and technological developments, the synthesis of novel and efficient antibacterial agents is required. In this work, nanoparticles of Ag, Cu, Au and Ag-Cu were supported on TiO2 Degussa P25 by the deposition-precipitation with urea method (DPU). The antibacterial performance of these materials, well known as catalysts of reactions of environmental interest, was evaluated against four different bac...
1 CitationsSource
#1Zhensheng Lin (PRC: China Medical University (PRC))H-Index: 1
#2Xiaoting Sun (PRC: China Medical University (PRC))H-Index: 2
Last. Huazhe Yang (PRC: China Medical University (PRC))H-Index: 11
view all 3 authors...
Abstract Magnesium-based biodegradable alloys exhibit excellent mechanical properties and bioactivity, which are favorable in the orthopedic applications. In addition, the degradation of Mg alloys results in an alkaline microenvironment which can effectively withstand bacteria. However, the degradation rate of Mg is too fast to sustain the healing process. And enhancement of its corrosion resistance may compromise the antibacterial ability, thus, alloying with antibacterial elements or doping th...
7 CitationsSource