Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity
Abstract
Gold nanoparticles (AuNPs) attached to the extracellular leaflet of the plasma membrane of neurons can enable the generation of action potentials (APs) in response to brief pulses of light. Recently described techniques to stably bind AuNP bioconjugates directly to membrane proteins (ion channels) in neurons enable robust AP generation mediated by the photoexcited conjugate. However, a strategy that binds the AuNP to the plasma membrane in a non...
Paper Details
Title
Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity
Published Date
Dec 27, 2018
Journal
Volume
10
Issue
3
Pages
1478 - 1487
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