Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles
Abstract
Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means to infer classical HLA alleles from inexpensive and dense SNP array data. In the research setting, imputation helps avoid costs for wet lab-based HLA typing and thus renders association analyses of the HLA in large cohorts feasible. Yet, most HLA imputation reference panels target Caucasian ethnicities and multi-ethnic panels are scarce. We compiled a...
Paper Details
Title
Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles
Published Date
Dec 26, 2018
Journal
Volume
28
Issue
12
Pages
2078 - 2092
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