Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Volume: 116, Issue: 2, Pages: 631 - 640
Published: Jan 8, 2019
Abstract
A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor...
Paper Details
Title
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
Published Date
Jan 8, 2019
Volume
116
Issue
2
Pages
631 - 640
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