Antimicrobial lavandulylated flavonoids from a sponge-derived actinomycete

Analysis of an antimicrobial culture broth extract of the sponge-derived actinomycete Streptomyces sp. (strain G246) led to the isolation of two new lavandulylated flavonoids, 6-lavandulyl-7-methoxy-5,2′,4′-trihydroxylflavanone (1) and 5′-lavandulyl-4′-methoxy-2,4,2′,6′-tetrahydroxylchalcone (2), along with eight known compounds 3–10. Their structures were established by spectral data analysis, including MS, 1D, 2D-NMR and CD. The absolute...