NMDA receptor dependence of reversal learning and the flexible use of cognitively demanding search strategies in mice

Cognitive flexibility helps organisms to respond adaptively to environmental changes. Deficits in this executive function have been associated with a variety of brain disorders, and it has been shown to rely on various concomitant neurobiological mechanisms. However, the involvement of the glutamatergic system in general, and NMDA receptors in particular, has been debated. Therefore, we injected C57BL/6 mice repeatedly with low-doses of the...