Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases
Abstract
SUMMARYBasic leucine zipper transcription factor 2 (Batf2) activation is detrimental in Type 1-controlled infectious diseases, demonstrated during infection with Mycobacterium tuberculosis (Mtb) and Listeria monocytogenes Lm. In Batf2-deficient mice (Batf2−/−), infected with Mtb or Lm, mice survived and displayed reduced tissue pathology compared to infected control mice. Indeed, pulmonary inflammatory macrophage recruitment, pro-inflammatory...
Paper Details
Title
Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases
Published Date
Mar 1, 2019
Journal
Volume
12
Issue
2
Pages
390 - 402
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