Albumin-Binding PSMA Ligands: Implications for Expanding the Therapeutic Window
Abstract
Despite significant gains in the treatment of metastatic castration-resistant prostate cancer by radioligands targeting prostate-specific membrane antigen (PSMA), 30% of patients never respond to therapy. One possible explanation is insufficient dose delivery to the tumor because of suboptimal pharmacokinetics. We have recently described RPS-063, a trifunctional ligand targeting PSMA with high uptake in LNCaP xenograft tumors but also in...
Paper Details
Title
Albumin-Binding PSMA Ligands: Implications for Expanding the Therapeutic Window
Published Date
Dec 14, 2018
Volume
60
Issue
5
Pages
656 - 663
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