Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids
Abstract
Sialic acid sugars on mammalian cells regulate numerous biological processes, while aberrant expression of sialic acid is associated with diseases such as cancer and pathogenic infection. Inhibition of the sialic acid biosynthesis may therefore hold considerable therapeutic potential. To effectively decrease the sialic acid expression, we synthesized C-5-modified 3-fluoro sialic acid sialyltransferase inhibitors. We found that C-5 carbamates...
Paper Details
Title
Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids
Published Date
Dec 13, 2018
Volume
62
Issue
2
Pages
1014 - 1021
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