Injectable PLGA microspheres with tunable magnesium ion release for promoting bone regeneration

Magnesium ions (Mg2+) are bioactive and proven to promote bone tissue regeneration, in which the enhancement efficiency is closely related to Mg2+ concentrations. Currently, there are no well-established bone tissue engineering scaffolds that can precisely control Mg2+ release, although this capability could have a marked impact in bone regeneration. Leveraging the power of biodegradable microspheres to control the release of bioactive factors,...