Interleukin-22 promotes tumor angiogenesis.

Published on May 1, 2019in Angiogenesis9.78
· DOI :10.1007/S10456-018-9658-X
Nicholas J. Protopsaltis2
Estimated H-index: 2
(UCSD: University of California, San Diego),
Wei Liang10
Estimated H-index: 10
(UCSD: University of California, San Diego)
+ 1 AuthorsNapoleone Ferrara179
Estimated H-index: 179
(UCSD: University of California, San Diego)
Sources
Abstract
TH17 cells play important yet complex roles in cancer development and progression. We previously reported that TH17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by TH17 cells, directly acts on endothelial cells to promote tumor angiogenesis. IL-22 induces endothelial cell proliferation, survival, and chemotaxis in vitro and neovascularization in an ex vivo mouse choroid explant model. Blockade of IL-22, with a neutralizing antibody, significantly inhibits tumor growth associated with reduced microvascular density. No synergistic effect of IL-22 with VEGF was observed. These results identify IL-22 as a potential therapeutic target for blocking tumor angiogenesis.
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