Interleukin-22 promotes tumor angiogenesis
Abstract
TH17 cells play important yet complex roles in cancer development and progression. We previously reported that TH17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by TH17 cells, directly acts on endothelial cells to promote tumor angiogenesis. IL-22 induces...
Paper Details
Title
Interleukin-22 promotes tumor angiogenesis
Published Date
Dec 11, 2018
Journal
Volume
22
Issue
2
Pages
311 - 323
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