Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update
Abstract
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types. Although the role of CDK2 in tumorigenesis has been controversial, emerging evidence proposes that selective CDK2 inhibition may provide a therapeutic benefit against certain tumors, and it continues to...
Paper Details
Title
Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update
Published Date
Dec 13, 2018
Volume
62
Issue
9
Pages
4233 - 4251
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