Visible spectrum

Physics

Radical

Catalysis

Organic chemistry

Chemistry

Acylation

Combinatorial chemistry

Silane

Silanes

Photoredox catalysis

Optoelectronics

Iodine

Photocatalysis

Photochemistry

Hypervalent molecule

Synthesis

Visible light photoredox catalysis has enabled easy access to acyl radicals under mild reaction conditions. Reactive acyl radicals, generated from various acyl precursors such as aldehydes, α-ketoacids, carboxylic acids, anhydrides, acyl thioesters, acyl chlorides, or acyl silanes, can undergo a diverse range of synthetically useful transformations, which were previously difficult or inaccessible. This review summarizes such recent progress of visible-light-driven acyl radical generation using transition metal photoredox catalysts, metallaphotocatalysts, hypervalent iodine catalysts or organic photocatalysts.

Acyl Radical Chemistry via Visible-Light Photoredox Catalysis