Physical Activity Is Associated with Attenuated Disease Progression in Chronic Obstructive Pulmonary Disease.

Published on May 1, 2019in Medicine and Science in Sports and Exercise5.411
· DOI :10.1249/MSS.0000000000001859
Heleen Demeyer20
Estimated H-index: 20
,
David Donaire-Gonzalez32
Estimated H-index: 32
+ 15 AuthorsJudith Garcia-Aymerich63
Estimated H-index: 63
Sources
Abstract
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength, and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. METHODS: We studied 114 COPD patients from the PAC-COPD cohort (94% male, mean [SD], 70 yr [8 yr] of age, 54 [16] forced expiratory volume in 1 s % predicted) at baseline and 2.6 yr (0.6 yr) later. Baseline PA was assessed by accelerometry. Multivariable general linear models were built to assess the association between PA and changes in lung function, functional exercise capacity, muscle strength, health status, and body composition. All models were adjusted for confounders and the respective baseline value of each measure. RESULTS: Per each 1000 steps higher baseline PA, forced expiratory volume in 1 s declined 7 mL less (P < 0.01), forced vital capacity 9 mL less (P = 0.03) and carbon monoxide diffusing capacity 0.10 mL·min·mm Hg less (P = 0.04), while the St George's Respiratory Questionnaire symptom domain deteriorated 0.4 points less (P = 0.03), per year follow-up. Physical activity was not associated with changes in functional exercise capacity, muscle strength, other domains of health status or body composition. CONCLUSIONS: Higher PA is associated with attenuated decline in lung function and reduced health status (symptoms domain) deterioration in moderate-to-very severe COPD patients.
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This work was supported by the Flemish Research Foundation (grant # G.0871.13) and PROactive IMI-JU # 115011. DL and WJ are post-doctoral research fellows of the FWO-Flanders. CAC is supported by CNPq/Brazil (202425/2011-8). Ms Heleen Demeyer is the recipient of a joint ERS/SEPAR Fellowship (LTRF 2015).
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The PAC-COPD Study is funded by grants from Fondo de Investigacion Sanitaria (FIS PI020541), Ministry of Health, Spain; Agencia d’Avaluacio de Tecnologia i Recerca Mediques (AATRM 035/20/02), Catalonia Government; Spanish Society of Pneumology and Thoracic Surgery (SEPAR 2002/137); Catalan Foundation of Pneumology (FUCAP 2003 Beca Maria Rava); Red RESPIRA (RTIC C03/11); Red RCESP (RTIC C03/09), Fondo de Investigacion Sanitaria (PI052486); Fondo de Investigacion Sanitaria (PI052302); Fundacio La ...
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