Physical Activity Is Associated with Attenuated Disease Progression in Chronic Obstructive Pulmonary Disease.

Published on May 1, 2019in Medicine and Science in Sports and Exercise5.411
· DOI :10.1249/MSS.0000000000001859
Heleen Demeyer20
Estimated H-index: 20
David Donaire-Gonzalez32
Estimated H-index: 32
+ 15 AuthorsJudith Garcia-Aymerich63
Estimated H-index: 63
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength, and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. METHODS: We studied 114 COPD patients from the PAC-COPD cohort (94% male, mean [SD], 70 yr [8 yr] of age, 54 [16] forced expiratory volume in 1 s % predicted) at baseline and 2.6 yr (0.6 yr) later. Baseline PA was assessed by accelerometry. Multivariable general linear models were built to assess the association between PA and changes in lung function, functional exercise capacity, muscle strength, health status, and body composition. All models were adjusted for confounders and the respective baseline value of each measure. RESULTS: Per each 1000 steps higher baseline PA, forced expiratory volume in 1 s declined 7 mL less (P < 0.01), forced vital capacity 9 mL less (P = 0.03) and carbon monoxide diffusing capacity 0.10 mL·min·mm Hg less (P = 0.04), while the St George's Respiratory Questionnaire symptom domain deteriorated 0.4 points less (P = 0.03), per year follow-up. Physical activity was not associated with changes in functional exercise capacity, muscle strength, other domains of health status or body composition. CONCLUSIONS: Higher PA is associated with attenuated decline in lung function and reduced health status (symptoms domain) deterioration in moderate-to-very severe COPD patients.
📖 Papers frequently viewed together
20122.21Heart & Lung
6 Authors (Chou-Chin Lan, ..., Yao-Kuang Wu)
#1Rafael Mesquita (UM: Maastricht University)H-Index: 15
#2Kenneth Meijer (UM: Maastricht University)H-Index: 39
Last. Martijn A. Spruit (UM: Maastricht University)H-Index: 77
view all 8 authors...
Abstract A more profound investigation about the responses in activity levels following pulmonary rehabilitation (PR) in patients with COPD is needed. We aimed to describe groups of patients with COPD according to patterns of change in physical activity and sedentary behaviour following PR. 90 patients with COPD (60% male; mean age 67 ± 8; median FEV 1 47 (32–62) %pred) completed a comprehensive PR programme. A triaxial accelerometer was used to assess the time in sedentary behaviour, light acti...
#8Sara C Buttery (ICL: Imperial College London)H-Index: 4
Rationale Reduced physical activity (PA) in patients with COPD is associated with a poor prognosis. Increasing PA is a key therapeutic target, but thus far few strategies have been found effective in this patient group. Objectives To investigate the effectiveness of a 12-week semiautomated telecoaching intervention on PA in patients with COPD in a multicentre European randomised controlled trial. Methods 343 patients from six centres, encompassing a wide spectrum of disease severity, were random...
#1Ulf Ekelund (Norwegian School of Sport Sciences)H-Index: 128
#2Jostein Steene-Johannessen (Norwegian School of Sport Sciences)H-Index: 32
Last. I-Min Lee (Harvard University)H-Index: 124
view all 8 authors...
Summary Background High amounts of sedentary behaviour have been associated with increased risks of several chronic conditions and mortality. However, it is unclear whether physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. We examined the associations of sedentary behaviour and physical activity with all-cause mortality. Methods We did a systematic review, searching six databases (PubMed, PsycINFO, Embase, Web of Science, Sport Discus, and Scopus) from...
#1Mark T. Dransfield (UAB: University of Alabama at Birmingham)H-Index: 65
#2Ken M. Kunisaki (UMN: University of Minnesota)H-Index: 16
Last. Barry J. Make (University of Colorado Denver)H-Index: 69
view all 17 authors...
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (COPD) increase the risk of death and drive healthcare costs, but whether they accelerate loss of lung function remains controversial. Whether exacerbations in subjects with mild COPD or similar acute respiratory events in smokers without airflow obstruction affect lung function decline is unknown.Objectives: To determine the association between acute exacerbations of COPD (and acute respiratory events in smokers without COP...
#1Jørgen Vestbo (University of Manchester)H-Index: 121
#2Julie A. Anderson (GSK: GlaxoSmithKline)H-Index: 29
Last. David E. Newby (Edin.: University of Edinburgh)H-Index: 108
view all 9 authors...
Summary Background Chronic obstructive pulmonary disease (COPD) often coexists with cardiovascular disease. Treatments for airflow limitation might improve survival and both respiratory and cardiovascular outcomes. The aim of this study was to assess whether inhaled treatment with a combined treatment of the corticosteroid, fluticasone furoate, and the long-acting β agonist, vilanterol could improve survival compared with placebo in patients with moderate COPD and heightened cardiovascular risk....
#1Heleen Demeyer (Katholieke Universiteit Leuven)H-Index: 20
#2Chris Burtin (Katholieke Universiteit Leuven)H-Index: 20
Last. Thierry Troosters (Katholieke Universiteit Leuven)H-Index: 84
view all 8 authors...
This work was supported by the Flemish Research Foundation (grant # G.0871.13) and PROactive IMI-JU # 115011. DL and WJ are post-doctoral research fellows of the FWO-Flanders. CAC is supported by CNPq/Brazil (202425/2011-8). Ms Heleen Demeyer is the recipient of a joint ERS/SEPAR Fellowship (LTRF 2015).
#1Maria Antonia Ramon (Autonomous University of Barcelona)H-Index: 9
#2Jaume Ferrer (Autonomous University of Barcelona)H-Index: 24
Last. Judith Garcia-Aymerich (UPF: Pompeu Fabra University)H-Index: 63
view all 18 authors...
The PAC-COPD Study is funded by grants from Fondo de Investigacion Sanitaria (FIS PI020541), Ministry of Health, Spain; Agencia d’Avaluacio de Tecnologia i Recerca Mediques (AATRM 035/20/02), Catalonia Government; Spanish Society of Pneumology and Thoracic Surgery (SEPAR 2002/137); Catalan Foundation of Pneumology (FUCAP 2003 Beca Maria Rava); Red RESPIRA (RTIC C03/11); Red RCESP (RTIC C03/09), Fondo de Investigacion Sanitaria (PI052486); Fondo de Investigacion Sanitaria (PI052302); Fundacio La ...
#1Erica P.A. Rutten (UM: Maastricht University)H-Index: 31
#2Martijn A. Spruit (University of Hasselt)H-Index: 77
Last. Emiel F.M. Wouters (UM: Maastricht University)H-Index: 134
view all 14 authors...
[Rutten, Erica P. A.; Spruit, Martijn A.; Franssen, Frits M. E.; Vanfleteren, Lowie; Wouters, Emiel F. M.] CIRO, Dept Res & Educ, Horn, Netherlands. [Rutten, Erica P. A.; Wouters, Emiel F. M.] Maastricht Univ, Med Ctr, NL-6200 MD Maastricht, Netherlands. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [McDonald, Merry-Lynn N.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02115 USA. [R...
#1Daniel Langer (Katholieke Universiteit Leuven)H-Index: 39
#2Noppawan Charususin (Katholieke Universiteit Leuven)H-Index: 7
Last. Rik Gosselink (Katholieke Universiteit Leuven)H-Index: 63
view all 7 authors...
Background Most inspiratory muscle training (IMT) interventions in patients with chronic obstructive pulmonary disease (COPD) have been implemented as fully supervised daily training for 30 minutes with controlled training loads using mechanical threshold loading (MTL) devices. Recently, an electronic tapered flow resistive loading (TFRL) device was introduced that has a different loading profile and stores training data during IMT sessions. Objective The aim of this study was to compare the eff...
Rationale: Little is known about the role of physical activity in the course of chronic obstructive pulmonary disease (COPD).Objectives: To assess changes in physical activity in COPD in relation to severity stages and changes in other disease components, and to evaluate the longitudinal association between sustained physical inactivity and disease progression.Methods: In this prospective cohort study, we measured physical activity (multisensory armband), airflow obstruction (FEV1), health statu...
Cited By10
#1Ashley Polhemus (UZH: University of Zurich)H-Index: 8
Last. Kristin Taraldsen (NTNU: Norwegian University of Science and Technology)H-Index: 16
view all 49 authors...
Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searche...
#1B. Chéhère (University of Western Brittany)
Last. F Costes (University of Auvergne)H-Index: 2
view all 3 authors...
Resume null null Introduction null L’activite physique (AP) des patients atteints de maladies respiratoires chroniques est souvent diminuee et associee a une augmentation du risque d’hospitalisation et de mortalite. Bien que le benefice du reentrainement a l’effort sur la sante des patients souffrant de maladies respiratoires chroniques soit bien etabli, son impact sur les AP est moins clair. null null null Etat de l’art null Evaluer l’AP et ses determinants est primordial dans une readaptation ...
#1Xander Bertels (UGent: Ghent University)
#2Lies Lahousse (UGent: Ghent University)H-Index: 30
#1Xiaoyu Han (SUS: Shanghai University of Sport)
#2Peijun Li (SUS: Shanghai University of Sport)H-Index: 6
Last. Weibing Wu (SUS: Shanghai University of Sport)H-Index: 6
view all 6 authors...
Physical inactivity is prevalent among patients with chronic obstructive pulmonary disease (COPD). Low physical activity (PA) levels worsen pulmonary function, exercise capacity, mortality, and hospital admissions of COPD patients; therefore, quality of life declines. Step counter-based PA promotion programs are proved to be effective ways to improve the PA of patients with COPD. This review summarizes the application of these programs in patients with COPD and discusses their effect on PA, exer...
#8Nicholas S Hopkinson (NIH: National Institutes of Health)H-Index: 62
Abstract Introduction Although mean physical activity in COPD patients declines by 400•500 steps/day annually, it is unknown whether the natural progression is the same for all patients. We aimed to identify distinct physical activity progression patterns using a hypothesis-free approach and to assess their determinants. Methods We pooled data from two cohorts (usual care arm of Urban Training [ NCT01897298 ] and PROactive initial validation [ NCT01388218 ] studies) measuring physical activity a...
#1Keenan A. Ramsey (VU: VU University Amsterdam)H-Index: 4
#2Anna G.M. Rojer (VU: VU University Amsterdam)H-Index: 5
Last. Andrea B. Maier (University of Melbourne)H-Index: 61
view all 10 authors...
Abstract Background Engaging in physical activity (PA) and avoiding sedentary behavior (SB) are important for healthy ageing with benefits including the mitigation of disability and mortality. Whether benefits extend to key determinants of disability and mortality, namely muscle strength and muscle power, is unclear. Aims This systematic review aimed to describe the association of objective measures of PA and SB with measures of skeletal muscle strength and muscle power in community-dwelling old...
#1Astrid Blondeel (Katholieke Universiteit Leuven)H-Index: 3
#2Heleen Demeyer (Katholieke Universiteit Leuven)H-Index: 20
Last. Thierry Troosters (Katholieke Universiteit Leuven)H-Index: 84
view all 4 authors...
Background Consumer-based activity trackers are used to measure and improve physical activity. However, the accuracy of these devices as clinical endpoint or coaching tool is unclear. We investigated the use of two activity trackers as measuring and coaching tool in patients with Chronic Obstructive Pulmonary Disease (COPD) and healthy age-matched controls. Methods Daily steps were measured by two consumer-based activity trackers (Fitbit Zip, worn at the hip and Fitbit Alta, worn at the wrist) a...
Background Patients with bronchiectasis have a less active lifestyle than healthy peers, but the association with hospital admission has not been explored. The aim of this study was to investigate the association between (i) any physical activity (PA) variable and (ii) sedentary time with hospitalisation due to exacerbation in adults with bronchiectasis. Methods In this prospective observational study, baseline lung function, quality of life, exercise tolerance, severity of bronchiectasis and PA...
#1Matthew Armstrong (Northumbria University)H-Index: 20
#2Andrew Winnard (Northumbria University)H-Index: 6
Last. Ioannis Vogiatzis (Northumbria University)H-Index: 37
view all 6 authors...
The aim of this study was to examine the use of pedometers as a tool to promote daily physical activity levels in patients with COPD.A systematic review meta-analysis of pedometer physical activity promotion in patients with COPD was conducted. Medline/PubMed, Cochrane Library, Web of Science and CINAHL were searched from inception to January 2019. The search strategy included the following keywords: physical activity promotion, pulmonary rehabilitation and daily physical activity. The eligibili...
#1Afroditi K. Boutou (ICL: Imperial College London)H-Index: 7
#2Yogini Raste (NIHR: National Institute for Health Research)H-Index: 7
Last. Nicholas S Hopkinson (NIHR: National Institute for Health Research)H-Index: 62
view all 11 authors...
Purpose: Longitudinal data on the effect of time and environmental conditions on physical activity (PA) among COPD patients are currently scarce, but this is an important factor in the design of trials to test interventions that might impact on it. Thus, we aimed to assess the effect of time and climate conditions (temperature, day length and rainfall) on progression of PA in a cohort of COPD patients. Patients and methods: This is a prospective, multicenter, cohort study undertaken as part of t...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.